« Back to Research Deepdives

Does Folate Lower Stroke Risk?

This content is restricted to members.

To view our premium content, sign up for a membership:

 

Register New Account

Choose your membership level

Choose Your Payment Method

‹ Back to Research Deepdives

References

1. Milani R v., Lavie CJ. Homocysteine: The Rubik’s Cube of Cardiovascular Risk Factors. Mayo Clinic Proceedings. 2008 Nov;83(11):1200–2.
2. Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, et al. Homocysteine-lowering by b vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: A randomized controlled trial. PLoS ONE. 2010;5(9):1–10.
3. de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: A randomized controlled trial. International Journal of Geriatric Psychiatry. 2012;27(6):592–600.
4. Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain v-3 fatty acids and B vitamin status in a randomized controlled trial. American Journal of Clinical Nutrition. 2015;102:215–21.
5. Brattström L, Wilcken D el. Homocysteine and cardiovascular disease: cause or effect? The American Journal of Clinical Nutrition. 2000 Aug 1;72(2):315–23.
6. Ganguly P, Alam SF. Role of homocysteine in the development of cardiovascular disease. Nutrition Journal. 2015 Dec 10;14(1):6.
7. Karger AB, Steffen BT, Nomura SO, Guan W, Garg PK, Szklo M, et al. Association Between Homocysteine and Vascular Calcification Incidence, Prevalence, and Progression in the MESA Cohort. J Am Heart Assoc. 2020 Feb 4;9(3).
8. Tanne D, Haim M, Goldbourt U, Boyko V, Doolman R, Adler Y, et al. Prospective Study of Serum Homocysteine and Risk of Ischemic Stroke Among Patients With Preexisting Coronary Heart Disease. Stroke. 2003 Mar;34(3):632–6.
9. Kim JM, Park KY, Shin DW, Park MS, Kwon OS. Relation of serum homocysteine levels to cerebral artery calcification and atherosclerosis. Atherosclerosis. 2016 Nov;254:200–4.
10. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists’ Collaboration. BMJ. 1998 Mar 21;316(7135):894–8.
11. Nygård O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, et al. Total Plasma Homocysteine and Cardiovascular Risk Profile. JAMA. 1995 Nov 15;274(19):1526.
12. Ueland PM, Refsum H, Beresford SA, Vollset SE. The controversy over homocysteine and cardiovascular risk. The American Journal of Clinical Nutrition. 2000 Aug 1;72(2):324–32.
13. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ. 2002 Nov 23;325(7374):1202–6.
14. Casas J, Bautista L, Smeeth L, Sharma P, Hingorani A. Homocysteine and stroke: evidence on a causal link from mendelian randomisation. The Lancet. 2005 Jan 15;365(9455):224–32.
15. Zeng R, Xu CH, Xu YN, Wang YL, Wang M. The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis. Public Health Nutrition. 2015 Jun 17;18(8):1514–21.
16. Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB. Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta‐Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2016 Aug 8;5(8): e003768.