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*Geek Box: Biomarkers

*Geek Box: Biomarkers of Dietary Intake "Biomarkers" are an attractive tool for nutrition science, particular epidemiology, as biomarkers may provide useful complementary data to dietary...
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*Geek Box: Postprandial Metabolism

*Geek Box: Postprandial Metabolism  ‘Post-prandial’ refers to the period after eating a meal. Therefore, ‘post-prandial glycaemia’ refers to blood glucose levels after a meal, while...
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*Geek Box: Open Label Trials

*Geek Box: Open Label Trials & Within-Person Comparisons ‘Open label’ means that both the researchers and the participants know what intervention the participants are receiving....
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*Geek Box: Omega-3 Supplement Forms

*Geek Box: Esters & Carboxylic Acids In order to understand the differences in the type of omega-3 fatty acids used in these studies, it is...
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*Geek Box: Phytosterols

*Geek Box: Phytosterols Phytosterols comprise both plant stanols and plant sterols, but there is no clinical or statistically relevant difference between the two regarding their...
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*Geek Box: Validity

*Geek Box: Validity We have discussed the concepts of reproducibility and validity in epidemiology in previous Deepdives, however, repetition always bears fruits in understanding. 'Reproducibility'...
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*Geek Box: Liver Fat

*Geek Box: Pathways of Hepatic Fat  How does fat get into the liver? There are a number of origins of hepatic fat, and the respective...
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*Geek Box: The LDL-Receptor

*Geek Box: The LDL-Receptor  A major breakthrough in cardiovascular sciences was achieved in 1974, when Joseph Goldstein and Micheal Brown discovered that a genetic defect...
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*Geek Box: Heterogeneity

*Geek Box: Heterogeneity When you read a meta-analysis, you will inevitably come across the term 'heterogeneity', which reflects statistical tests for heterogeneity between the included...
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*Geek Box: NOS

*Geek Box: The Newcastle-Ottawa Scale The Newcastle-Ottawa Scale (NOS) is a grading tool to assess the quality of non-randomised trials included in a meta-analysis. Observational...
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*Geek Box: The Vitamin K Cycle

*Geek Box: The Vitamin K Cycle Yes, vitamin K has it’s own ‘cycle’, which makes it one of those cooler nutrients. Vitamin K differs to other fat-soluble vitamins, which are...
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*Geek Box: ROBINS-E

*Geek Box: ROBINS-E The Risk of Bias in Non-Randomized Studies of Exposures [ROBINS-E] is a tool for grading risk of bias, one of several tools...
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