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Melatonin and Insulin Resistance: What is the Link?

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References

  1. Arendt J, Skene DJ. Melatonin as a chronobiotic. Sleep Med Rev. 2005;9(1):25–39.
  2. Reiter RJ. Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*. Endocr Rev. 1991 May;12(2):151–80.
  3. Navarro-Alarcón M, Ruiz-Ojeda FJ, Blanca-Herrera RM, A-Serrano MM, Acuña-Castroviejo D, Fernández-Vázquez G, et al. Melatonin and metabolic regulation: A review. Food Funct. 2014;5(11):2806–32.
  4. Haljas K, Hakaste L, Lahti J, Isomaa B, Groop L, Tuomi T, et al. The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits: the prospective PPP-Botnia study. Ann Med. 2019 Jan 2;51(1):58–67.
  5. Garaulet M, Gómez-Abellán P, Rubio-Sastre P, Madrid JA, Saxena R, Scheer FAJL. Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans. Metabolism. 2015 Dec;64(12):1650–7.
  6. Xia Q, Chen ZX, Wang YC, Ma YS, Zhang F, Che W, et al. Association between the Melatonin Receptor 1B Gene Polymorphism on the Risk of Type 2 Diabetes, Impaired Glucose Regulation: A Meta-Analysis. PLoS One. 2012 Nov 30;7(11):e50107.
  7. Eckel RH, Depner CM, Perreault L, Markwald RR, Smith MR, McHill AW, et al. Morning Circadian Misalignment during Short Sleep Duration Impacts Insulin Sensitivity. Current Biology. 2015;25(22):3004–10.
  8. Flanagan A, Bechtold DA, Pot GK, Johnston JD. Chrono-nutrition: From molecular and neuronal mechanisms to human epidemiology and timed feeding patterns. J Neurochem. 2021;157(1):53–72.
  9. Cain SW, Dennison CF, Zeitzer JM, Guzik AM, Khalsa SBS, Santhi N, et al. Sex Differences in Phase Angle of Entrainment and Melatonin Amplitude in Humans. J Biol Rhythms. 2010 Aug 2;25(4):288–96.
  10. Jeong J, Zhu H, Harris RA, Dong Y, Su S, Tingen MS, et al. Ethnic Differences in Nighttime Melatonin and Nighttime Blood Pressure: A Study in European Americans and African Americans. Am J Hypertens. 2019 Sep 24;32(10):968–74.
  11. Tam CS, Xie W, Johnson WD, Cefalu WT, Redman LM, Ravussin E. Defining Insulin Resistance From Hyperinsulinemic-Euglycemic Clamps. Diabetes Care. 2012 Jul 1;35(7):1605–10.
  12. Spiegel K, Leproult R, van Cauter E. Impact of sleep debt on metabolic and endocrine function. The Lancet. 1999 Oct;354(9188):1435–9.
  13. Benloucif S, Burgess HJ, Klerman EB, Lewy AJ, Middleton B, Murphy PJ, et al. Measuring melatonin in humans. Journal of Clinical Sleep Medicine. 2008;4(1):66–9.
  14. Baron KG, Reid KJ, Wolfe LF, Attarian H, Zee PC. Phase Relationship between DLMO and Sleep Onset and the Risk of Metabolic Disease among Normal Weight and Overweight/Obese Adults. J Biol Rhythms. 2018;33(1):76–83.
  15. McHill AW, Czeisler CA, Phillips AJK, Keating L, Barger LK, Garaulet M, et al. Caloric and macronutrient intake differ with circadian phase and between lean and overweight young adults. Nutrients. 2019;11(3).
  16. McHill AW, Phillips AJK, Czeisler CA, Keating L, Yee K, Barger LK, et al. Later circadian timing of food intake is associated with increased body fat. American Journal of Clinical Nutrition. 2017;106(5):1213–9.
  17. Garaulet M, Lopez-Minguez J, Dashti HS, Vetter C, Hernández-Martínez AM, Pérez-Ayala M, et al. Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. Diabetes Care. 2022 Mar 1;45(3):512–9.